Pfizer drug breach ends in biggest US crime fine

The history of Pfizer & legal claims

25 years ago, Pfizer sent a team to Nigeria during a meningococcal meningitis outbreak. They conducted an “open label” (unblinded) clinical trial involving 200 children, half of whom were given Pfizer’s new antibiotic Trovan and half of whom received the gold standard treatment, ceftriaxone. Watchdogs noted that Pfizer used substantially lower doses of ceftriaxone to rig the trials in favor of Trovan. 11 Nigerian children died: 5 after receiving Pfizer’s product and 6 after receiving lower-than-normal doses of the older drug.

One 10-year-old girl suffering from meningitis was not taken off experimental Trovan and given standard, proven treatments by Pfizer –when it was clear that her condition was deteriorating.

Pfizer paid the largest fine for health care fraud in American history ($2.3 billion) in 2009 to resolve allegations that it illegally caused false claims to be submitted to the government and paid kickbacks to health care providers to induce them to prescribe their products (see below).

Nearly 3,000 people developed suicidal thoughts and severe psychological disorders after taking Pfizer’s smoking cessation drug, Chantix. Pfizer paid out nearly $300 million to settle those cases.

10,000 women won claims of nearly $1 billion after developing breast cancer linked to Pfizer’s Prempro hormone
replacement therapy.

“Pfizer pleaded guilty to misbranding the painkiller Bextra, withdrawn from the market in 2004, by promoting the drug for uses that were not approved by medical regulators.

They also settled civil allegations concerning improper payments to doctors who prescribed nine other pharmaceutical products, although it continues to deny these charges.”

2014 “Pfizer reached a $190 million settlement agreement over claims that it manipulated the drug market to increase prices on its epilepsy drug Neurontin, resolving claims that the drug maker promoted the medication for unapproved uses and engaged in allegedly frivolous lawsuits against generic manufacturers.”

2016 “Pfizer Inc PFE.N on Tuesday said it has reached a $486 million settlement of litigation accusing it of causing big losses for shareholders by concealing safety risks associated with its Celebrex and Bextra pain-relieving drugs.”

Lyrica, a drug manufactured by Pfizer, was initially developed to treat epilepsy. Since that time, it’s been prescribed off-label to treat pain and anxiety — often with disastrous results. In addition to suicidal thoughts, use of Lyrica has been associated with respiratory depression; slowed breathing can be dangerous on its own, and the chance of fatality only increases when the user is elderly, has a pre-existing lung condition, or uses Opioids in combination with Lyrica.

The US Department of Justice fined Pfizer $2.3 billion for breaking the law in how it promoted 4 of its drugs, including Lyrica, in 2009. At the time, the settlement was the largest health care fraud payout in history. To date, it’s the second largest.

The UK Supreme Court has thrown out an appeal by the drug company Pfizer over its blockbuster drug pregabalin (Lyrica).

A recent study has linked the anti-seizure drug Lyrica with a tripled increased risk of birth defects when it is used early in pregnancy. About 6% of babies exposed to Lyrica had a heart defect, nervous system defect, or organ defect.

List of largest pharmaceutical settlements – includes Pfizer and others.


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3 thoughts on “Pfizer drug breach ends in biggest US crime fine

  1. Staff, I really like your reporting. You report on things that is not reported by the normal news sources. Please continue with that.
    Regarding donating, I think many subscribers, like myself would rather pay for a subscription rather than donate.
    There is another news source that does a lot of similar reporting and they have a subscription fee of 49.99 per year, which I gladly pay and was willing to pay more than that, Maybe you can make it optional, allowing those who want to pay for a subscription to sign for a year at a reasonable price but you could continuing to make it available to others for donation of any amount, etc. But please setup a reasonable subscription rate and I will gladly sign up.


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