Abstract
..”Fully vaccinated were more likely than unvaccinated persons to be infected by variants carrying mutations associated with decreased antibody neutralization … but not by those associated with increased infectivity ….
Differences in viral loads were non-significant between unvaccinated and fully vaccinated persons overall ….
Viral loads were significantly higher in symptomatic as compared to asymptomatic vaccine breakthrough cases… and symptomatic vaccine breakthrough infections had similar viral loads to unvaccinated infections….
In 5 cases with available longitudinal samples for serologic analyses, vaccine breakthrough infections were found to be associated with low or undetectable neutralizing antibody levels attributable to immunocompromised state or infection by an antibody-resistant lineage.
These findings suggest that vaccine breakthrough cases are preferentially caused by circulating antibody-resistant SARS-CoV-2 variants, and that symptomatic breakthrough infections may potentially transmit COVID-19 as efficiently as unvaccinated infections, regardless of the infecting lineage”
Link: https://www.medrxiv.org/content/10.1101/2021.08.19.21262139v1
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