Vitamin D deficiency and COVID-19: A case-control study at a tertiary care hospital in India

Vitamin D status appears to be strongly associated with COVID-19 clinical severity. After COVID-19 confirmation, Vitamin D level should be measured in all patients and curative plus preventive therapy should be initiated.

August 2021,

Abstract

Background: As the pandemic COVID-19 affected developing and developed countries, there is no proven treatment options available yet. The anti-inflammatory, antiviral and immune modulator effect of Vitamin D could be beneficial to COVID-19.

Aim: To find out the possible association between Vitamin D and COVID-19.

Methods: The present case-control study was conducted at tertiary care hospital, AIIMS, Patna, Bihar, India. Total 156 cases and 204 controls were enrolled in the study after obtaining informed consent. Categorization of the patients were done based on clinical severity and level of Vitamin D. The association between these categories with different variables were analyzed using regression analysis and other statistical tests.

Results: The status of Vitamin D (optimal, mild to moderate deficiency and severe deficiency) differed significantly among cases and controls. Diabetes and hypertension were most prevalent comorbidities among cases. On regression analysis, the difference in Vitamin D level was significant (aOR, 3.295; 95%CI, 1.25-8.685). The association between Vitamin D status and clinical severity group was statistically significant among cases. Among all variables, age, diabetes, hypertension and clinical severity were associated with worst outcome.

Conclusion: Vitamin D status appears to be strongly associated with COVID-19 clinical severity. After COVID-19 confirmation, Vitamin D level should be measured in all patients and curative plus preventive therapy should be initiated.

Keywords: COVID-19; Case-control; Clinical severity; Vitamin D.

References

  1. Hoffmann M., Kleine-Weber H., Schroeder S. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181:271–280. doi: 10.1016/j.cell.2020.02.052. e8. – DOI – PMC – PubMed

https://pubmed.ncbi.nlm.nih.gov/34377451/

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One thought on “Vitamin D deficiency and COVID-19: A case-control study at a tertiary care hospital in India

  1. Many safe effective and cheap remedies for Covid, including vitamin D, have been heavily censored. So that a perceptive 10 year old can see, and could see from the start, that Covid-19 has nothing to do with real science (ie, it’s a scam).

    Here is WHY even most so-called intelligent people CANNOT figure that out… read “The 2 Married Pink Elephants In The Historical Room –The Holocaustal Covid-19 Coronavirus Madness: A Sociological Perspective & Historical Assessment Of The Covid “Phenomenon”” by Rolf Hefti at https://www.rolf-hefti.com/covid-19-coronavirus.html

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